Paper
Mechanism for gastric antisecretory effects of desmethylimipramine in rats.
Published Nov 5, 1981 · R. Pendleton, J. Mccafferty, J. Roesler
European journal of pharmacology
Q1 SJR score
17
Citations
0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Study Snapshot
Desmethylimipramine reduces gastric acid secretion in rats by inhibiting catecholamine uptake at central synapses containing 2 -adrenoceptors.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
The blockade of α2-adrenoceptors by the PNMT inhibitor SK&F 64139
SK&F 64139 and SK&F 72223 are 2-adrenoceptor antagonists, while SK&F 29661 is inactive as a PNMT inhibitor.
1980·32citations·M. Goldstein et al.·European Journal of Pharmacology
European Journal of Pharmacology
Pharmacological specificity of brain histamine H2-receptors differs in intact cells and cell-free preparations
Brain histamine H2-receptors show distinct drug discriminatory properties in intact cells and cell-free preparations, potentially impacting their molecular basis for clinical antidepressant activity.
1980·54citations·M. Tuong et al.·Nature
Nature
Effects of α-adrenoceptor agonists and antagonists and of antidepressant drugs on pre-and postsynaptic α-adrenoceptors
Antidepressants, except for viloxazine, all possess postsynaptic -adrenoceptor antagonist properties, with mianserin being the most potent antagonist at presynaptic -adrenoceptors.
1980·58citations·Janet Brown et al.·European Journal of Pharmacology
European Journal of Pharmacology
Long-term antidepressant treatment decreases spiroperidol-labeled serotonin receptor binding.
Long-term antidepressant treatment decreases serotonin and beta-adrenergic receptor binding, but this effect is not correlated with clinical efficacy.
1980·825citations·Stephen J. Peroutka et al.·Science
Science
STRUCTURE‐ACTIVITY RELATIONSHIPS OF CLONIDINE‐ AND TOLAZOLINE‐LIKE COMPOUNDS AT HISTAMINE AND α‐ADRENOCEPTOR SITES
The most potent clonidine- and tolazoline-like compounds are those with 2,6-phenyl substituents, which restrict rotation and have greater influence on histamine H2 activity than receptor effects.
1980·14citations·E. Malta et al.·British Journal of Pharmacology
British Journal of Pharmacology
Citations
Decreased Gastric Acid Output Following Neuropeptide Y Administration into the Lateral Cerebral Ventricle of Conscious Rats a
Injection of NPY into the cerebral ventricles of conscious rats leads to decreased gastric acid output, with the adrenergic nervous system playing a role in this response.
1990·15citations·S. Penner et al.·Annals of the New York Academy of Sciences
Annals of the New York Academy of Sciences
Involvement of metabolites in the inhibitory effects of 2-(4-ethyl-1-piperazinyl)-4-phenylquinoline dimaleate (AD-2646), a new quinoline derivative, on gastric acid secretion. A comparison with tricyclic antidepressants.
AD-2646, a new quinoline derivative, inhibits gastric acid secretion more effectively when applied intraduodenally than subcutaneously, likely due to greater efficiency in the formation of active metabolites.
1989·2citations·Y. Kimura et al.·Journal of pharmacobio-dynamics
Journal of pharmacobio-dynamics
Lidamidine inhibits intrinsic contractile patterns of the rat proximal colon.
Lidamidine inhibits intrinsic colonic contractions in rats primarily through an 2-receptor-mediated mechanism.
1987·4citations·D. Decktor et al.·European journal of pharmacology
European journal of pharmacology
Effects of α2‐agonists upon colonic propulsion
Clonidine and lidamidine effectively decrease colonic propulsion in mice, with their effects selectively blocked by 2antagonists.
1986·8citations·R. Pendleton et al.·Drug Development Research
Drug Development Research
POSTER COMMUNICATIONS
Denzimol induces tolerance in mice, potentially due to central nervous system adaptation or induction of hepatic microsomial enzymes.
1985·0citations·C. Daly et al.·British Journal of Pharmacology
British Journal of Pharmacology
Pharmacology of the treatment of peptic ulcer disease
Anti-ulcer drugs can be categorized into corticohypothalamic, antisecretory, antacids, mucosa protecters, and gastric muscle stimulants, with new compounds like synthetic prostaglandins and inhibitors of H+/K+-ATPase potentially offering
1985·6citations·G. Bertaccini et al.·Digestive Diseases and Sciences
Digestive Diseases and Sciences
Effects of substantia nigra lesions on the volumes of A, B, and D cells and the content of insulin and glucagon in the rat pancreas
Substantial nigra lesions in rats do not increase B-cell volume density, but pancreatic insulin and glucagon content increases, suggesting the substantia nigra plays a role in controlling islet growth and development.
1985·10citations·B. Davis et al.·Diabetologia
Diabetologia
Gastric hypersecretion by intracisternal TRH: dissociation from hypophysiotropic activity and role of central catecholamine.
Intracisternal TRH stimulation of gastric secretion is unrelated to its hypophysiotropic activity and requires the integrity of the central but not peripheral catecholaminergic system.
1985·39citations·Y. Taché et al.·European journal of pharmacology
European journal of pharmacology