G. Improta
Mar 1, 1980
Citations
0
Influential Citations
3
Citations
Quality indicators
Journal
Pharmacological research communications
Abstract
Summary Methanol extracts of the skin of Phyllomedusa sauvagei, a South American hylid frog, contain an active polypeptide, sauvagine , which has been isolated in a pure form and shown to be constituted by a straight chain of 40 amino acid residues. The polypeptide displayed in the rat an intense hypotensive action, that is probably the main cause of the intense antidiuresis observed in hydrated rats. The reduction in urine volume was accompanied by a decrease in glomerular filtration rate, and by an increase in tubular sodium and potassium reabsorption and in plasma aldosterone concentration.