The molecular mechanisms that underpin the biological benefit of full spectrum cannabis extract in the treatment of neuropathic pain and inflammation.

doi:10.1016/j.bbadis.2020.165771

Paper

The molecular mechanisms that underpin the biological benefit of full spectrum cannabis extract in the treatment of neuropathic pain and inflammation.

Published Mar 19, 2020 · Zaid H Maayah, S. Takahara, M. Ferdaoussi

Biochimica et biophysica acta. Molecular basis of disease

UNKNOWN SJR score

59

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3

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Abstract

Abstract removed due to Elsevier request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Literature Review

Study Snapshot

Key takeawayFull-spectrum cannabis extracts, not just purified cannabinoids, show potential biological benefits in treating neuropathic pain and inflammation.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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The molecular mechanisms that underpin the biological benefit of full spectrum cannabis extract in the treatment of neuropathic pain and inflammation.

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References

Intestinal Bacteria Interplay With Bile and Cholesterol Metabolism: Implications on Host Physiology

Intestinal bacteria play a crucial role in bile and cholesterol metabolism, shaping gut microbiota profiles and impacting host health.

The neuropsychopharmacology of cannabis: A review of human imaging studies

Cannabis and THC have acute effects on various neurocognitive systems, with heavy repeated use, particularly during adolescence, increasing the risk of mental illnesses like addiction and psychosis.

Cannabidiol in patients with Lennox‐Gastaut syndrome: Interim analysis of an open‐label extension study

Cannabidiol (CBD) shows potential in improving long-term safety and efficacy in patients with Lennox-Gastaut syndrome.

Cannabidiol: A New Hope for Patients With Dravet or Lennox-Gastaut Syndromes

Cannabidiol (CBD) significantly reduces seizures as an adjunct to standard antiepileptic therapies in patients 2 years old with Dravet syndrome and Lennox-Gastaut syndrome, offering a new treatment option for refractory seizures.

An experimental randomized study on the analgesic effects of pharmaceutical-grade cannabis in chronic pain patients with fibromyalgia

Inhaled pharmaceutical-grade cannabis showed complex effects on chronic pain patients with fibromyalgia, with some analgesic responses after a single inhalation, but further studies are needed.

Citations

Cannabinoids: Role in Neurological Diseases and Psychiatric Disorders

Cannabis and its cannabinoids show potential as therapeutic alternatives in neurological diseases and psychiatric disorders by modulating physiological functions and disease progression.

A systematic review of Cannabis sativa L. cultivation techniques: A comprehensive overview of tissue culture innovations and growth optimization

This systematic review highlights the need for standardized tissue culture methods and genotype-specific challenges to optimize Cannabis sativa production.

A Preliminary Investigation into the Use of Cannabis Suppositories and Online Mindful Compassion for Improving Sexual Function Among Women Following Gynaecological Cancer Treatment

Cannabis suppositories and online mindfulness-compassion interventions can improve sexual function and reduce sexual pain in women after gynecological cancer treatment.

Evaluation of the Efficacy of a Full-Spectrum Low-THC Cannabis Plant Extract Using In Vitro Models of Inflammation and Excitotoxicity

NTI-164, a high-cannabidiol, low-THC cannabis extract, shows potential anti-inflammatory and neuroprotective effects on microglia and neurons, suggesting potential as a treatment for neuropathologies.

Harnessing Cannabis sativa Oil for Enhanced Skin Wound Healing: The Role of Reactive Oxygen Species Regulation

Cannabis oil may enhance skin wound healing by reducing reactive oxygen species and upregulating antioxidative mechanisms, but further research is needed to optimize formulations for therapeutic applications.