Mechanisms of vasorelaxant effect of dehydroevodiamine: a bioactive isoquinazolinocarboline alkaloid of plant origin.

doi:10.1097/00005344-199606000-00012

Paper

Mechanisms of vasorelaxant effect of dehydroevodiamine: a bioactive isoquinazolinocarboline alkaloid of plant origin.

Published Jun 1, 1996 · W. Chiou, J. Liao, Andrew Yau-Chik Shum

Journal of cardiovascular pharmacology

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31

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1

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Abstract

We examined the mechanisms underlying the vasorelaxant effect of dehydroevodiamine (DeHE), one of the bioactive components of the Chinese herbal drug Evodia rutaecarpa that has been shown to produce vasorelaxant and hypotension. DeHE (10(-7)-10(-4) M) concentration-dependently relaxed isolated rat mesenteric arteries precontracted with phenylephrine (PE). This vasorelaxant potency was diminished by 15% by endothelial removal, L-NG-nitro arginine, or methylene blue (MB), but not indomethacin treatment, indicating that the vasorelaxant effect of DeHE was partially endothelium dependent and mediated by nitric oxide (NO) and the cyclic GMP pathway. In endothelium-denuded preparations, DeHE caused a rightward shift of the contractile concentration-response curve (CRC) to PE in a dose-dependent manner with a pA2 value of 6.15. Maximal response was unaffected. Receptor binding assay indicated that DeHE competed with alpha 1-adrenoceptor ligand prazosin with a Ki value of 3.57 microM. Potassium channel activity-attenuating conditions such as increased level of extracellular K+ (20 mM) and treatment with the antagonist tetraethylammonium (TEA) significantly inhibited DeHE's effect, suggesting a mode of action similar to that of a potassium channel activator. In addition, high concentrations of DeHE (3 x 10(-5) and 10(-4) M) relaxed high K+ (80 mM)-evoked contraction, indicating that DeHE might possess K+ channel blocking properties. Multiple-action mechanisms, including endothelium dependence, alpha 1-adrenoceptor blockade, K+ channel activation, and Ca2+ channel blockade were probably involved in the vasorelaxant effects of DeHE.

In Vitro Study

Study Snapshot

Dehydroevodiamine (DeHE) relaxes arteries partially through endothelium dependence and multiple mechanisms, including nitric oxide, cyclic GMP pathway, and potassium channel activation.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Mechanisms of vasorelaxant effect of dehydroevodiamine: a bioactive isoquinazolinocarboline alkaloid of plant origin.

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References

The mechanism of the vasodilator effect of rutaecarpine, an alkaloid isolated from Evodia rutaecarpa.

Rutaecarpine's vasodilator effect is endothelium-dependent and involves nitric oxide and guanylyl cyclase, but not muscarinic, histamine H 1, or 2-adrenoceptors, and may

Study on the vascular reactivity and α1‐adrenoceptors of portal hypertensive rats

Vascular hyporesponsiveness to noradrenaline in the mesenteric artery or tail artery of portal hypertensive rats is not due to changes in the affinity or number of 1-adrenoceptors.

Do the K+ channel openers relax smooth muscle by opening K+ channels?

The K+ channel openers relax smooth muscle by opening K+ channels, leading to hyperpolarization and relaxation of the tissue.

Ionic mechanisms responsible for the antiarrhythmic action of dehydroevodiamine in guinea‐pig isolated cardiomyocytes

Dehydroevodiamine alkaloid (DeHE) may depress triggered arrhythmias in calcium-overloaded guinea-pig cardiac myocytes through inhibitory actions on INa, Iti, and ICa, and class III antiarrhythmic effect through reducing outward K current

The vasorelaxant effect of evodiamine in rat isolated mesenteric arteries: mode of action.

Evodiamine's vasodilator effect in rat mesenteric arteries is primarily mediated by blocking calcium influx through receptor-mediated channels, with no evidence of K+ channel activation.

Citations

Major Indole Alkaloids in Evodia Rutaecarpa: The Latest Insights and Review of Their Impact on Gastrointestinal Diseases.

Evodiamine, rutaecarpine, and dedhydroevodiamine show potential in alleviating gastrointestinal inflammation and having anti-cancer effects, with EVO showing the strongest anti-cancer effect.

Research Progress in Pharmacological Action of Dehydroevodiamine

Dehydroevodiamine, found in Fructus officinalis herb, can inhibit inflammation, reduce oxidative stress, and potentially treat Alzheimer's disease, memory dysfunction, and various other diseases.

Pharmacological mechanism of natural drugs and their active ingredients in the treatment of arrhythmia via calcium channel regulation.

Natural drugs and their active ingredients effectively treat arrhythmias by regulating calcium channels, offering potential for innovative antiarrhythmic drug development.

Traditional Chinese medicine

Traditional Chinese medicine, using herbal formulations, shows potential for treating various diseases, but requires rigorous scientific validation and rigorous Western methodologies.

Role of plant derived alkaloids as antioxidant agents for neurodegenerative diseases

Plant-derived alkaloids show potential as antioxidant agents for neurodegenerative diseases by targeting oxidative stress mechanisms.