Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytes.

doi:10.1016/S0014-2999(03)01378-5

Paper

DOI: 10.1016/S0014-2999(03)01378-5

Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytes.

Published Mar 28, 2003 · Yuh-Chiang Shen, W. Chiou, Yueh-Ching Chou

European journal of pharmacology

Q1 SJR score

230

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

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Study Snapshot

Baicalin and baicalein reduce inflammation in human leukocytes by impairing reactive oxygen intermediates production or inhibiting Mac-1-dependent leukocyte adhesion.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Andrographolide prevents oxygen radical production by human neutrophils: possible mechanism(s) involved in its anti‐inflammatory effect

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Effects of baicalein isolated from Scutellaria baicalensis Radix on adhesion molecule expression induced by thrombin and thrombin receptor agonist peptide in cultured human umbilical vein endothelial cells.

Baicalein from Scutellaria baicalensis Radix effectively inhibits adhesion molecule expression induced by thrombin and thrombin receptor agonist peptide in human umbilical vein endothelial cells, potentially benefiting blood vessel health.

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Antioxidant therapy: a new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury.

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Citations

DOI: 10.3389/fimmu.2025.1551256

Baicalin mitigates hyperglycemia-linked intestinal epithelial barrier impairment in part by inhibiting the formation of neutrophil extracellular traps

Baicalin protects against hyperglycemia-linked intestinal epithelial barrier impairment by inhibiting neutrophil extracellular trap formation, potentially reducing diabetic complications.

2025·0citations·Yiqing Cai et al.·Frontiers in Immunology

Frontiers in Immunology

DOI: 10.3390/antiox14030248

Identifying Baicalein as a Key Bioactive Compound in XueBiJing Targeting KEAP1: Implications for Antioxidant Effects

Baicalein is a key bioactive compound in XueBiJing, driving its antioxidant and anti-inflammatory effects through activation of the KEAP1/NRF2 pathway through direct binding to KEAP1.

2025·0citations·Ting-Syuan Lin et al.·Antioxidants

Antioxidants

DOI: 10.1038/s41598-024-68528-y

Baicalin target protein, Annexin A2, is a target of new antitumor drugs

Baicalin's antitumor and apoptosis-inducing effects are mediated by Annexin A2, suggesting that agents inhibiting this protein could be useful candidates for developing novel antitumor agents.

2024·1citation·Yoshio Kusakabe et al.·Scientific Reports

Scientific Reports

DOI: 10.1016/j.virs.2024.07.003

Baicalein suppresses Coxsackievirus B3 replication by inhibiting caspase-1 and viral protease 2A

Baicalein has antiviral activity against Coxsackievirus B3 infection and may serve as a potential therapeutic option for myocarditis caused by enterovirus infection.

2024·4citations·Yanyan Dong et al.·Virologica Sinica

Virologica Sinica

DOI: 10.1016/j.intimp.2024.112445

Multimodal modulation of hepatic ischemia/reperfusion-induced injury by phytochemical agents: A mechanistic evaluation of hepatoprotective potential and safety profiles.

Natural herbal ingredients like ginseng, curcumin, resveratrol, and lycopene show promising hepatoprotective effects against ischemia/reperfusion injury in animal models.

2024·3citations·Deiaa E Elsayed Abouzed et al.·International immunopharmacology

International immunopharmacology