Metabolic activation of 2,6-dichlorobenzonitrile, an olfactory-specific toxicant, by rat, rabbit, and human cytochromes P450.

doi:10.1016/s0026-895x(25)09010-8

Paper

DOI: 10.1016/s0026-895x(25)09010-8

Metabolic activation of 2,6-dichlorobenzonitrile, an olfactory-specific toxicant, by rat, rabbit, and human cytochromes P450.

Published Jun 1, 1996 · Xinxin Ding, D. Spink, Jay K. Bhama

Molecular pharmacology

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Study Snapshot

The herbicide 2,6-dichlorobenzonitrile causes tissue-specific toxicity in rodents' olfactory mucosa, with cytochrome P450s of the 2A subfamily playing a key role in its metabolism.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

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Olfactory mucosal necrosis in rats following acute intraperitoneal administration of 1,2-diethylbenzene, 1,2-diacetylbenzene and 2,5-hexanedione.

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