F. Johannsen, C. O. Knowles
Feb 1, 1974
Citations
0
Influential Citations
7
Citations
Quality indicators
Journal
Journal of economic entomology
Abstract
The metabolic fate of fluenethyl (FIU) or 2-fluoroethyl (4-biphenylyl) acetate was studied in the mouse, the house fly, Musca domestica L., and the twospotted spider mite, Tetranychus urticae Koch. Excretion balance data indicated that FlU-3H equivalents were eliminated at a moderate rate in mouse urine and feces, following intraperitoneal injection of the acaricide. FIU metabolites identified in mouse urine included biphenylacetic acid, 2-hydroxybiphenyl, 4-hydroxybiphenyl, and 4, 4′-dihydroxybiphenyl; biphenyl and 3, 4-dihydroxybiphenyl were tentatively identified. Biphenylacetic acid and the hydroxylated biphenyls occurred in mouse urine in the free form and as glucuronides and ethereal sulfates. FIU also was degraded enzymatically by subcellular fractions prepared from a mouse liver homogenate, and nonenzymatically by a model hydroxylation system. Degradation products were biphenylacetic acid and the hydroxylated biphenyls. Metabolism of FIU-3H was effected in vivo and in vitro by house flies and twospotted spider mites. Although quantitative differences were apparent, qualitatively the metabolites were identical to the free compounds isolated from mouse urine, with the exception that 2-hydroxybiphenyl was not detected in spider mites. Plasma from the human, mouse, sheep, and pig also catalyzed the degradation of FIU-3H. Biphenylacetic acid was the major product, and its formation in this and the other in vitro studies was inhibited by DFP (di iso propyl phosphorofluoridate).