Yuan-zheng Zhao, Yiran Ren, Zhen-qing Liu
May 13, 2021
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Quality indicators
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Social Science Research Network
Abstract
3, 4-dicaffeoylquinic acid (3, 4 - DiCQA) is a dicaffeoylquinic acid, which possesses antioxidant, anti-inflammatory, antibacterial, antiviral, anticancer, hypoglycemic, hypotensive and hepatoprotective activities. In this study, a method using ultra-high performance liquid chromatography equipped with linear ion trap-orbitrap mass spectrometry (UHPLC-LTQ - Orbitrap MS) was developed to identify the metabolites of 3, 4 - DiCQA in rat plasma, urine, feces and tissues. The metabolic profile of 3, 4 - DiCQA was determined after oral administration to rats at a dose of 200 mg/kg. A total of 67 metabolites were observed and characterized for the first time, combined with accurate mass measurement, diagnostic ions, neutral losses and reference standards. The results indicated that hydrolysis, methylation, hydrogenation, hydration, dehydroxylation, dehydrogenation, sulphate conjunction and glucuronide conjunction were the major metabolic reactions of 3, 4 - DiCQA in vivo.