L. Ondi, Jean-Noël Volle, M. Schlosser
Jan 17, 2005
Citations
1
Influential Citations
8
Citations
Journal
Tetrahedron
Abstract
Mono- and disubstituted 2-bromo-3-fluoroquinolines 3 are readily accessible. They can be converted into the 3-fluoroquinoline-2-carboxylic acids 5 by consecutive halogen/metal permutation and into the 2-bromo-3-fluoroquinoline-4-carboxylic acids 6 by consecutive deprotonation and carboxylation. The latter compounds can be reduced to afford the 3-fluoroquinoline-4-carboxylic acids 7. The yields are excellent throughout. Rather than to introduce one functional group alternatively at the 2- or 4-position, one may also attach two different functional groups sequentially to both sites.