Andrii Monastyrskyi, Niranjan K. Namelikonda, Roman Manetsch
Feb 24, 2015
Citations
1
Influential Citations
36
Citations
Journal
The Journal of organic chemistry
Abstract
A clean arylation protocol of ethyl acetoacetate was developed using hypervalent diaryliodonium salts under mild and metal-free conditions. The scope of the reaction, using symmetric and unsymmetric iodonium salts with varying sterics and electronics, was examined. Further, this method has been applied for the synthesis of antimalarial compound ELQ-300, which is currently in preclinical development.