Metal-halogen exchange reactions of 1,5-diiodonaphthalene. Synthesis of 1,5-disubstituted naphthalene derivatives

doi:10.1021/JO00008A059

Paper

Metal-halogen exchange reactions of 1,5-diiodonaphthalene. Synthesis of 1,5-disubstituted naphthalene derivatives

Published Apr 1, 1991 · Wuyi Wang, S. D'Andrea, J. Freeman

Journal of Organic Chemistry

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Abstract

We felt that 1,5-diiodonaphthalene (2) would be ideally suited for our purposes, since it was potentially a precursor both of organometallic reagents and of compounds derived from nucleophilic substitution. Also, 2 could be prepared readily from commercially available 1,5-diaminonaphthalene (1) by diazotization/KI. This paper describes our efforts in the preparation of 1,5-disubstituted naphthalenes derived from 2

Study Snapshot

This paper presents the preparation of 1,5-disubstituted naphthalene derivatives from 1,5-diiodonaphthalene, a promising precursor for organometallic reagents and nucleophilic substitution.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Metal-halogen exchange reactions of 1,5-diiodonaphthalene. Synthesis of 1,5-disubstituted naphthalene derivatives

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References

Citations

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5-alkylthebaines, 5-alkyl-10-ethylthebaines, and 5,10,10-triethylthebaine are useful precursors for the synthesis of opium alkaloids.