L. F. B. Duarte, Eduardo S. Barbosa, R. L. Oliveira
Aug 16, 2017
Citations
0
Influential Citations
22
Citations
Journal
Tetrahedron Letters
Abstract
Abstract We described here an alternative method for the synthesis of 4-arylselanyl-7-chloroquinolines through reactions of 4,7-dichloroquinoline with organylselenols, generated in situ by the reaction of diorganyl diselenides with H 3 PO 2 (50 wt% in H 2 O). These reactions proceeded efficiently at 60 °C under N 2 atmosphere and are suitable to a range of diorganyl diselenides containing electron-donating and electron-withdrawing groups, affording the corresponding 4-aryl-7-chloroquinolines in high yields. The synthesized compounds were screened for their in vitro acetylcholinesterase (AChE) activity and our results demonstrated that the 7-chloro-4-[(4-fluorophenyl)selanyl]quinoline inhibited the AChE activity and improved memory in mice, making this compound is a potential therapeutic agent for the treatment of Alzheimer disease and other neurodegenerative disorders.