Jiawei Lin, Wei Wu, Z. Weng
Nov 19, 2020
Citations
0
Influential Citations
2
Citations
Journal
Tetrahedron Letters
Abstract
Abstract An efficient reaction of vinyl azides with difluoroacetic anhydride or chlorodifluoroacetic anhydride has been developed. It involved sequential difluoroacetylation of vinyl azides, followed by deprotonation, cyclization, and dinitrogen elimination, providing a convenient synthesis of both 5-difluoromethyl and 5-chlorodifluoromethyl isoxazoles at yields up to 89%. 2009 Elsevier Ltd. All rights reserved.