Bhavna Gupta, B. R. Babu, Kapil Gyanda
Jan 31, 2014
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0
Influential Citations
2
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Journal
Letters in Organic Chemistry
Abstract
The stereoselective synthesis of an antifungal drug, Terbinafine, bearing ( E)-tert-butylenyne structural element as the side chain is achieved by coupling N-methyl-1-napthalene methanamine with 1-bromo-6,6-dimethyl-2 E-hepten-4- yne in good yield. The new methodology avoids the use of toxic starting materials like acrolein and phosphorous penta- chloride that were used in earlier reports. The structure was confirmed by IR, NMR, MS, and elemental analysis.