Norio Hashimoto, T. Aoyama, T. Shioiri*
Jan 25, 1982
Citations
0
Influential Citations
36
Citations
Journal
Chemical & Pharmaceutical Bulletin
Abstract
Trimethylsilyldiazomethane (TMSCHN2) easily reacts with various ketones in the presence of boron trifluoride etherate in methylene chloride solution to give chain- or ring-homologated ketones, and can be used as a stable and safe substitute for hazardous diazomethane. The reaction proceeds below 0°C during 1-4h, and permits much more efficient homologation than can be achieved with diazomethane.