A. Coop, C. Cunningham, L. Thatcher
Apr 1, 2006
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Influential Citations
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Citations
Journal
Heterocycles
Abstract
Trimethylsilyldiazomethane (TMS-CHN 2 ) is a convenient agent for the methylation of acidic alcohols, and is known to methylate non-acidic alcohols in CH 2 Cl 2 by the addition of HBF 4 . Herein, we show that silica gel acts as a suitable alternative for alkaloids, without causing precipitation of the salt from the reaction mixture.