Hong‐Gang Cheng, Maoping Pu, Gourab Kundu
Dec 13, 2019
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Influential Citations
14
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Journal
Organic letters
Abstract
We herein disclose the use of tetramethylammonium fluoride (TMAF) as a direct and selective methylating agent of a variety of amides, indoles, pyrroles, imidazoles, alcohols, and thiols. The method is characterized by operational simplicity, wide scope, and ease of purification. Our computational studies suggest a concerted methylation-deprotonation as the preferred reaction pathway.