Structural and Microbiological Characterization of 5-Hydroxy-3,7,4'-Trimethoxyflavone: A Flavonoid Isolated from Vitex gardneriana Schauer Leaves.

doi:10.1089/mdr.2018.0359

Paper

Structural and Microbiological Characterization of 5-Hydroxy-3,7,4'-Trimethoxyflavone: A Flavonoid Isolated from Vitex gardneriana Schauer Leaves.

Published Apr 4, 2019 · I. Macedo, J. H. Da Silva, P. T. da Silva

Microbial drug resistance

Q2 SJR score

19

Citations

1

Influential Citations

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Abstract

INTRODUCTION Staphylococcus aureus represents the most common etiologic agent of purulent infections, affecting humans and animals. Escherichia coli is one of the principal causes of infectious diseases, mainly diarrheal diseases due to enterotoxin action. There are many reports indicating that these bacteria are multidrug-resistant (MDR) pathogens. OBJECTIVE In this study, we investigated the antimicrobial and modulatory activities of 5-hydroxy-3,7,4'-trimethoxyflavone (VG.EF.CLII) against E. coli and S. aureus strains. METHODS 5-Hydroxy-3,7,4'-trimethoxyflavone was isolated from Vitex gardneriana Schauer leaves and structurally characterized using nuclear magnetic resonance. The antibacterial effect of VG.EF.CLII and modulation of antibiotic activity, both determined by minimum inhibitory concentration, were assessed using microtiter plates. RESULTS VG.EF.CLII showed bacterial growth inhibition at concentrations ≤512 μg/mL, and synergistic effects were observed for the modulation of two distinct antibiotic classes (the fluoroquinolone norfloxacin and the aminoglycoside gentamicin). CONCLUSION 5-Hydroxy-3,7,4'-trimethoxyflavone isolated from V. gardneriana showed promising antimicrobial activity against MDR bacterial strains S. aureus 358 and E. coli 27 when associated with the antibiotics norfloxacin and gentamicin. Therefore, this natural product can contribute to the control of bacterial resistance.

In Vitro Study

Study Snapshot

5-Hydroxy-3,7,4'-trimethoxyflavone from Vitex gardneriana Schauer leaves shows promising antimicrobial activity against multidrug-resistant S. aureus and E. coli strains, contributing to bacterial resistance control.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Structural and Microbiological Characterization of 5-Hydroxy-3,7,4'-Trimethoxyflavone: A Flavonoid Isolated from Vitex gardneriana Schauer Leaves.

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References

Phytochemical characterization of the Baccharis dracunculifolia DC (Asteraceae) essential oil and antibacterial activity evaluation

Baccharis dracunculifolia essential oil shows promising antimicrobial potential, both directly and in combination with antibiotics, for clinical use against Gram-positive and Gram-negative bacteria.

In vitro e in silico evaluation of the inhibition of Staphylococcus aureus efflux pumps by caffeic and gallic acid.

Caffeic acid effectively inhibits Staphylococcus aureus efflux pumps, potentially offering a new treatment option for resistant strains.

Essential oil of Eucalyptus camaldulensis Dehn potentiates β-lactam activity against Staphylococcus aureus and Escherichia coli resistant strains

Eucalyptus camaldulensis Dehn essential oil shows antimicrobial activity and potential as a resistance modifier against Staphylococcus aureus and Escherichia coli resistant strains, offering a new therapeutic resource against these pathogens.

Vanillin selectively modulates the action of antibiotics against resistant bacteria.

Vanillin selectively modulates the activity of antibiotics against multiresistant bacteria, potentially aiding in the development of new therapies against resistant microorganisms.

Spectroscopic and microbiological characterization of labdane diterpene 15,16-epoxy-4-hydroxy-labda-13(16),14-dien-3,12-dione isolated from the stems of Croton jacobinensis

The labdane diterpene 15,16-epoxy-4-hydroxy-labda-13(16),14-dien-3,12-dione from Croton jacobinensis stems shows a modulatory effect and synergistic effect with gentamicin against Escherich

Citations

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Chromolaena odorata flavonoid compounds show promising antimycobacterial and hepatoprotective potential, potentially leading to safe and effective anti-tubercular drugs.

Phytochemical Constituents Isolated From Distichochlamys citrea M.F. Newman Rhizomes and Their Antioxidant and α-glucosidase Inhibitory Activities

Distichochlamys citrea rhizomes contain flavonoids, phenolics, sterols, and monoglycerides, which exhibit antioxidant properties and -glucosidase inhibitory effects, potentially benefiting health.

Success stories of natural product-derived compounds from plants as multidrug resistance modulators in microorganisms

Natural product-derived compounds from plants show potential as safer and more effective antimicrobial drugs against multidrug-resistant microorganisms, offering new sources for pharmaceutical industries.

Perspectives on the enhancement of commercially available antibiotics by natural products

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