K. Chimi, S. Katsuda, N. Taba
Jun 5, 1987
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Journal
Journal of The Food Hygienic Society of Japan (shokuhin Eiseigaku Zasshi)
Abstract
The effects of gonyautoxins (GTXs) on neuromuscular transmission and impulse conduction in the nerve were studied in the sciatic-nerve sartorius-muscle preparation of a frog. The preparation was placed in an experimental chamber and immersed in Ringer's solution. End plate potential (EPP) was recorded through a glass micropipette advanced into the muscle fiber near the motor nerve terminal. Action potential (AP) of the motor nerve was monitored simultaneously with EPP through a micropipette kept in contact with the motor nerve on the surface of the muscle. EPP suddenly disappeared about 3min after exposure of the preparation to Ringer's solution containing GTXs (0.1MU/ml) and abruptly recovered in amplitude and waveform to the control level 5min after wash-out of the toxins from the preparation. AP was completely abolished by the application of GTXs and this effect was also reversed by the removal of the toxins. However, prolongation of latency was observed in the restored EPP and AP. These results suggest that GTXs might suppress impulse conduction along the motor nerve and inhibit EPP.