Nicolò Scalacci, Chiara Pelloja, M. Radi
Apr 7, 2016
Citations
0
Influential Citations
11
Citations
Journal
Synlett
Abstract
Abstract A simple and versatile microwave-assisted protocol for the synthesis of 2-aminothiazoles has been developed. The domino reaction of propargylamines and isothiocyanates in the presence of catalytic PTSA leads to the selective synthesis of 2-aminothiazoles at temperatures above 130 °C and in a few minutes. The same reaction carried out at lower temperatures leads to the formation of the tautomeric 2-amino-4-methylenethiazolines.