S. Leyva‐Ramos, E. Leyva, Jaime Cardoso-Ortiz
Oct 12, 2017
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Journal
Revista de la Sociedad Química de Mexico
Abstract
A simple and efficient two-step method was implemented for the synthesis of ethyl 7-chloro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate. Comparing with the reported Grohe-Heitzer reaction, the time and the reaction steps have been reduced using microwave irradiation. This compound is an important intermediate for the preparation of naphthyridone derivatives which have received significant attention due to their broad spectrum of biological activity.