T. R. Riggs, S. Węgrzyn
1966
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Journal
Endocrinology
Abstract
Daily injections of testosterone, methyltestosterone, nortestosterone or 9α-fluoro-llβ-hydroxy-17α-niethyltestosterone produced a marked decrease in the 24-hr urinary excretion of an administered dose of 14C-α-aminoisobutyric acid in the immature female rat. 11-Epicortisol more than doubled the 24-hr urinary loss. The retention of the amino acid produced by the first 4 steroids led to a significant increase in the AIB level in the serum in each case. Methyltestosterone and the fluoro derivative increased the transport of AIB into skeletal and heart muscles, while testosterone and epicortisol increased the transport into skeletal muscle. The treatment with thefluoromethyltestosterone or nortestosterone produced a significant decrease in transport into the kidney. Epicortisol elevated the transport of the amino acid into the liver, demonstrating that the steroid possesses this activity in common with hydrocortisone. (Endocrinology 78: 137, 1966)