H. Shigeura
Dec 1, 1963
Citations
0
Influential Citations
7
Citations
Journal
The Journal of biological chemistry
Abstract
Previous work from this laboratory demonstrated that hadacidin (N-formylhydroxyaminoacetate) inhibited the biosynthesis & luwo of adenylic acid in Ehrlich ascites tumor and rat liver cells. This effect, which was shown to be due to the inhibition of adenylosuccinate synthetase (IMP : L-aspartate ligase (1))) was competitively reversed by L-aspartate (2, 3). The structural similarity between aspartic acid and its metabolic analogue, hadacidin, is shown in Formula 1.