Rongwei Guo, Terry T.‐L. Au‐Yeung, Jing Wu
Nov 26, 2002
Citations
0
Influential Citations
15
Citations
Journal
Tetrahedron-asymmetry
Abstract
Abstract (S)- and (R)-2,2′-Bis[bis(3,5-dimethylphenyl)phosphinoyl]-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl (Xyl-H8-BINAPO) were synthesised by reacting chlorobis(3,5-dimethylphenyl)phosphine with (S)- and (R)-2,2′-dihydroxyl-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl, respectively. The applications of these ligands and their corresponding parent analogues in the Rh-catalysed asymmetric hydrogenation of a variety of acetamidoacrylic acids and esters provided chiral amino acid derivatives with good to excellent ee's (up to 97%).