Yan Zhi-wei
2009
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Journal
Chinese Journal of Health Laboratory Technology
Abstract
Objective:To analyze enantiomer profiling of methamphetamine in urine to provide technical support for regulation of the precursors and investigation of the drug case.Methods:In the present study,we investigated the enantiomer ratios of 35 urine specimens.The methamphetamine isomers were derivatized with(S)-(+)-a-methoxy-a-(trifluoromethyl)phenylacetyl chloride((S)-(+)-MTPACl),and the derivatives were analyzed by GC-MS in full scan monitoring mode.Results:Most of the specimens were pure S(+)-enantiomer(89%),but 4 samples contained R(-)-enantiomer.Conclusion:The majority of drugs are prepared from either(1R,2S)-(-)-ephedrine or(1S,2S)-(+)-pseudoephedrine.Meanwhile,there are methamphetamine drugs synthesized from(1S,2R)-(-)-ephedrine or(1R,2R)-(+)-pseudoephedrine.