P. Keane, J. Kan, N. Sontag
Sep 1, 1979
Citations
0
Influential Citations
18
Citations
Quality indicators
Journal
Journal of Pharmacy and Pharmacology
Abstract
Rats were administered toloxatone 100 mg kg−1 p.o., and killed 0·5 to 8 hours later. Toloxatone reversibly inhibited type A MAO, but did not affect the activity of type B MAO in whole brain. Cerebral concentrations of noradrenaline, dopamine and 5‐hydroxytryptamine were increased after toloxatone, while their metabolite concentrations were reduced. Synaptosomal uptake processes of these amines were not altered by toloxatone.