V. Potkin, S. Petkevich, A. Lyakhov
Dec 18, 2012
Citations
0
Influential Citations
4
Citations
Journal
Synthesis
Abstract
By a series of successive transformations, 5-arylisoxazole-3-carboxylic acids (aryl = phenyl, p -tolyl, 2,5-dimethylphenyl) have been converted into 5-arylisoxazole-3-hydroxamic acids, which undergo rearrangement by the action of aqueous KOH to form 3,4-substituted 1,2,5-oxadiazoles. The structure of one of them, 1-(2,5-dimethylphenyl)-2-(4-hydroxy-1,2,5-oxadiazol-3-yl)ethanone, has been confirmed by single crystal X-ray analysis.