Eye movements in neurodegenerative diseases.

doi:10.1097/WCO.0000000000000274

Paper

Eye movements in neurodegenerative diseases.

Published Feb 1, 2016 · M. MacAskill, T. Anderson

Current opinion in neurology

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80

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1

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Abstract

PURPOSE OF REVIEW Abnormalities of oculomotor control accompany the pathological changes underlying many neurodegenerative diseases. Clinical examination of eye movements can contribute to differential diagnosis, whereas quantitative laboratory measures can provide detailed insight into the disease process. In this review of eye movements in neurodegenerative disease, we summarise recent empirical findings and conceptual advances. RECENT FINDINGS Oculomotor researchers continue to be particularly prolific in studying Parkinson's disease but there is also substantial activity in Alzheimer's disease and spinocerebellar ataxia. Interesting findings have been reported in Huntington's, motor neuron disease, and glaucoma. Most studies report laboratory-based investigations but useful progress in clinical description continues to be made. SUMMARY Eye movements remain an active field of investigation across a variety of neurodegenerative conditions. Progress continues to be made at the clinical level as well by using laboratory techniques.

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Study Snapshot

Key takeawayEye movements play a crucial role in various neurodegenerative diseases, aiding in diagnosis and providing insights into the disease process.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Eye movements in neurodegenerative diseases.

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Combining deep brain stimulation with eye movement analysis can be a powerful research tool for understanding oculomotor physiology, basal ganglia pathophysiology, and the mechanism of action of DBS in Parkinson's disease.

Patients with mild Alzheimer’s disease produced shorter outgoing saccades when reading sentences

Patients with mild Alzheimer's disease exhibit reduced forward saccades during reading, potentially revealing impairments in working memory, memory retrieval, and semantic memory functions at early stages of the disease.

The Neuropathology of Huntington’s Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy

Neuropathological findings in Huntington's disease have progressed over time, with recent findings highlighting the involvement of specific brain regions and their pathophysiological relevance for the clinical phenotype.

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