Mathieu Bibian, A. Blayo, A. Moulin
May 12, 2010
Citations
0
Influential Citations
21
Citations
Journal
Tetrahedron Letters
Abstract
Abstract We report a new method using silver benzoate instead of mercury salts as a key reagent for the synthesis of 3,4,5-trisubstituted 1,2,4-triazoles. This method allows the introduction of a large variety of substituents in the three positions. We demonstrated that we could introduce one chiral center without any loss of the optical purity. This method is compatible with at least multi-gram scale-up.