Judy Szeto, Vi-Anh Vu, J. Malerich
Dec 6, 2018
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Influential Citations
6
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Journal
Journal of Flow Chemistry
Abstract
AbstractThe development of a flow chemistry approach to the anti-fungal fluconazole is described. A continuous, two-reactor, three-step synthesis of fluconazole from 2-chloro-2′,4′-difluoroacetophenone was achieved with no intermediate purification. The synthesis has been successfully demonstrated on a Vapourtec commercial flow chemistry system. Graphical abstractᅟ