Muscles provide protection during microbial infection by activating innate immune response pathways in Drosophila and zebrafish

doi:10.1242/dmm.022665

Paper

Muscles provide protection during microbial infection by activating innate immune response pathways in Drosophila and zebrafish

Published Jun 1, 2016 · Arunita Chatterjee, Debasish Roy, E. Patnaik

Disease Models & Mechanisms

Q1 SJR score

20

Citations

2

Influential Citations

Full textSemantic Scholar

Abstract

ABSTRACT Muscle contraction brings about movement and locomotion in animals. However, muscles have also been implicated in several atypical physiological processes including immune response. The role of muscles in immunity and the mechanism involved has not yet been deciphered. In this paper, using Drosophila indirect flight muscles (IFMs) as a model, we show that muscles are immune-responsive tissues. Flies with defective IFMs are incapable of mounting a potent humoral immune response. Upon immune challenge, the IFMs produce anti-microbial peptides (AMPs) through the activation of canonical signaling pathways, and these IFM-synthesized AMPs are essential for survival upon infection. The trunk muscles of zebrafish, a vertebrate model system, also possess the capacity to mount an immune response against bacterial infections, thus establishing that immune responsiveness of muscles is evolutionarily conserved. Our results suggest that physiologically fit muscles might boost the innate immune response of an individual. Summary: Using fruit fly and zebrafish models, we show that skeletal muscles are immune responsive tissues; they mount innate immune responses during bacterial infection – an evolutionarily conserved defense mechanism.

Rigorous Journal

Study Snapshot

Key takeawayMuscles in fruit flies and zebrafish can activate innate immune responses to protect against bacterial infections, suggesting a conserved defense mechanism.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Muscles provide protection during microbial infection by activating innate immune response pathways in Drosophila and zebrafish

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Citations

Drosophila Innate Immunity Involves Multiple Signaling Pathways and Coordinated Communication Between Different Tissues

Drosophila innate immunity involves multiple signaling pathways and coordinated communication between different tissues, providing a powerful model for studying human innate immunity-related diseases.

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IKKγ/NEMO Is Required to Confer Antimicrobial Innate Immune Responses in the Yellow Mealworm, Tenebrio Molitor

TmIKK plays a crucial role in the yellow mealworm's antimicrobial innate immune response, regulating antimicrobial peptide genes after microbial challenges.