M. Zaw, N. A. Emran, Zaw Lin
Sep 1, 2018
Citations
6
Influential Citations
123
Citations
Quality indicators
Journal
Journal of infection and public health
Abstract
BACKGROUND Rifampicin (RIF) plays a pivotal role in the treatment of tuberculosis due to its bactericidal effects. Because the action of RIF is on rpoB gene encoding RNA polymerase β subunit, 95% of RIF resistant mutations are present in rpoB gene. The majority of the mutations in rpoB gene are found within an 81bp RIF-resistance determining region (RRDR). METHODOLOGY Literatures on RIF resistant mutations published between 2010 and 2016 were thoroughly reviewed. RESULTS The most commonly mutated codons in RRDR of rpoB gene are 531, 526 and 516. The possibilities of absence of mutation in RRDR of rpoB gene in MDR-TB isolates in few studies was due to existence of other rare rpoB mutations outside RRDR or different mechanism of rifampicin resistance. CONCLUSION Molecular methods which can identify extensive mutations associated with multiple anti-tuberculous drugs are in urgent need so that the research on drug resistant mutations should be extended.