Mycoplasma pneumoniae: susceptibility and resistance to antibiotics.

doi:10.2217/fmb.11.18

Paper

Mycoplasma pneumoniae: susceptibility and resistance to antibiotics.

Published Apr 28, 2011 · C. Bébéar, S. Pereyre, O. Peuchant

Future microbiology

Q2 SJR score

154

Citations

9

Influential Citations

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Abstract

Mycoplasma pneumoniae is a pathogenic mycoplasma responsible for respiratory tract infections in humans, which occurs worldwide in children and adults. This article focuses on its antibiotic susceptibility profile and on the development of acquired resistance in this microorganism. The lack of a cell wall in mycoplasmas makes them intrinsically resistant to β-lactams and to all antimicrobials that target the cell wall. M. pneumoniae is susceptible to macrolides and related antibiotics, tetracyclines and fluoroquinolones. Macrolides and related antibiotics are the first-line treatment for respiratory infections caused by M. pneumoniae. However, strains with acquired resistance to macrolides have recently emerged worldwide and have been spreading in Europe, USA and A sia especially, with more than 90% of Chinese isolates resistant to erythromycin and azithromycin. This acquired resistance can be detected by PCR methods directly from respiratory specimens and is related to 23S rRNA mutations.

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Study Snapshot

Mycoplasma pneumoniae is resistant to -lactams and susceptible to macrolides, tetracyclines, and fluoroquinolones, but acquired resistance to macrolides is emerging worldwide, affecting first-line treatment for respiratory infections.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Mycoplasma pneumoniae: susceptibility and resistance to antibiotics.

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References

Macrolide resistance determination and molecular typing of Mycoplasma pneumoniae by pyrosequencing.

Pyrosequencing is a convenient technique for detecting macrolide resistance in Mycoplasma pneumoniae and for molecular typing of isolates.

Characterization of macrolide resistance in Mycoplasma pneumoniae isolated from children in Shanghai, China.

Macrolide resistance in Mycoplasma pneumoniae strains from pediatric patients in Shanghai, China, is 90%, with 88.9% harboring an A-to-G transition mutation in 23S rRNA genes.

High prevalence of macrolide resistance in Mycoplasma pneumoniae isolates from adult and adolescent patients with respiratory tract infection in China.

Macrolide resistance is prevalent in Mycoplasma pneumoniae, requiring longer antibiotic therapy and longer fever resolution in adult and adolescent patients with respiratory tract infections in China.

Occurrence of macrolide-resistant Mycoplasma pneumoniae strains in Germany.

Macrolide-resistant Mycoplasma pneumoniae strains are present in Germany, indicating a limited but not negligible importance in the population studied.

Macrolide-resistant Mycoplasma pneumoniae: characteristics of isolates and clinical aspects of community-acquired pneumonia

Macrolide-resistant Mycoplasma pneumoniae has rapidly increased in prevalence in pediatric and adult patients with community-acquired pneumonia, highlighting the need for improved surveillance and treatment strategies.

Citations

Novel mechanisms of macrolide resistance revealed by in vitro selection and genome analysis in Mycoplasma pneumoniae

Midecamycin is less potent in inducing resistance than other macrolides, suggesting it could be a potential first treatment choice for Mycoplasma pneumoniae infections.

The molecular characteristics, diagnosis, and treatment of macrolide-resistant Mycoplasma pneumoniae in children

Marolide-resistant Mycoplasma pneumoniae in children is a widespread infection with limited treatment effects, and additional corticosteroids may be needed for severe infections in China.

Green synthesised CuNPs using Alhagi maurorum extract and its ability to amelioration of Mycoplasma pneumoniae infected pneumonia mice model

Green-synthesised CuNPs using Alhagi maurorum extract show potential in reducing inflammation and improving lung function in Mycoplasma pneumoniae-infected mice.

The Monitoring of Mycoplasma gallisepticum Minimum Inhibitory Concentrations during the Last Decade (2010–2020) Seems to Reveal a Comeback of Susceptibility to Macrolides, Tiamulin, and Lincomycin

Mycoplasma gallisepticum has regained susceptibility to common antimicrobial drugs like erythromycin, tylosin, tilmicosin, spiramycin, tiamulin, and lincomycin, indicating a comeback in its

Antibiotic perturbation of gut bacteria does not significantly alter host responses to ocular disease in a songbird species

Gut bacterial disruption does not significantly alter host responses to ocular disease in house finches, but may impact pro-inflammatory cytokine stimulation.