H. L. Deak, J. Newcomb, J. J. Nunes
Feb 1, 2008
Citations
0
Influential Citations
10
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
N-3-(Phenylcarbamoyl)arylpyrimidine-5-carboxamides are a novel class of selective Lck inhibitors. This series of compounds derives its selectivity from a hydrogen bond with the gatekeeper Thr316 of the enzyme. X-ray co-crystal structural data, structure-activity relationships, and the synthesis of these inhibitors are reported herein.