N-Acetylaspartylglutamate: possible role as the neurotransmitter of the lateral olfactory tract.

doi:10.1073/PNAS.82.11.3897

Paper

N-Acetylaspartylglutamate: possible role as the neurotransmitter of the lateral olfactory tract.

Published Jun 1, 1985 · J. ffrench-Mullen, K. Koller, R. Zaczek

Proceedings of the National Academy of Sciences of the United States of America

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149

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Abstract

N-Acetylaspartylglutamate, an endogenous brain peptide that binds with high affinity to a subpopulation of glutamate-binding sites in rat brain, is excitatory on rat piriform cortex pyramidal cells studied in a perfused brain slice. Both the monosynaptic excitation of the pyramidal cells elicited by stimulation of the lateral olfactory tract and the response to N-acetylaspartylglutamate were blocked by DL-2-amino-4-phosphonobutyrate but not by other excitatory amino acid antagonists. Responses to glutamate and aspartate, previously considered to be candidates as the lateral olfactory tract transmitter, were unaffected by 2-amino-4-phosphonobutyrate. Three days after unilateral bulbectomy there was a significant decrease in concentrations of N-acetylaspartylglutamate as well as aspartate, N-acetylaspartate, and gamma-aminobutyrate in the pyriform cortex of the side from which the olfactory bulb had been removed. These results are consistent with the possibility that N-acetylaspartylglutamate is the endogenous transmitter of the lateral olfactory tract.

In Vitro Study

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Study Snapshot

N-acetylaspartylglutamate may be the endogenous transmitter of the lateral olfactory tract, as it is excitatory on rat piriform cortex pyramidal cells and shows decreased concentrations in the pyriform cortex after olfactory bulbectomy.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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N-Acetylaspartylglutamate: possible role as the neurotransmitter of the lateral olfactory tract.

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References

Citations

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N‐Acetylaspartylglutamate

NAAG is a neurotransmitter that plays a diverse role in the mammalian nervous system, affecting long-term potentiation and depression, and potentially inhibiting transmitter release and producing extracellular glutamate after hydrolysis.