The cortical neuropeptide, cortistatin-14, impairs post-training memory processing

doi:10.1016/S0006-8993(97)01084-6

Paper

DOI: 10.1016/S0006-8993(97)01084-6

The cortical neuropeptide, cortistatin-14, impairs post-training memory processing

Published Nov 14, 1997 · J. Flood, K. Uezu, J. Morley

Brain Research

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Abstract

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Non-RCT

Animal Study

Study Snapshot

Cortistatin-14 impairs post-training memory processing in mice at doses of 0.5-5.0 g.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Intrahippocampal injection of Cortistatin-14 impairs recognition memory consolidation in mice through activation of sst2, ghrelin and GABAA/B receptors

Cortistatin-14 impairs recognition memory consolidation in mice through activation of sst2, ghrelin, and GABA systems, with its memory-impairing effects reversed by c-SOM, cyanamid154806, [d-Lys3]GHRP-6,

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Cortistatin—Functions in the central nervous system

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