Neurotoxic and biochemical properties of some triaryl phosphates.

doi:10.1016/0006-2952(61)90162-9

Paper

DOI: 10.1016/0006-2952(61)90162-9

Neurotoxic and biochemical properties of some triaryl phosphates.

Published May 1, 1961 · W. Aldridge, J. Barnes

Biochemical pharmacology

Q1 SJR score

Citations

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Study Snapshot

Triaryl phosphates show no correlation with neurotoxicity in chickens, but all four compounds inhibit liver and intestinal phenyl butyrate esterase activity in vitro and in vivo.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Full text analysis coming soon...

References

DOI: 10.1042/BJ0670423

Liver and brain mitochondria.

The protein content of mitochondrial suspensions was expressed as mg. of albumin, with the liver and brain mitochondria having higher protein content than the kidney.

1957·112citations·W. Aldridge·The Biochemical journal

The Biochemical journal

DOI: 10.1038/176259A0

Metabolism of Triaryl Phosphates in Rodents

Tri-o-cresyl phosphate is converted into an active inhibitor of esterases in rodents, potentially causing demyelination and paralysis.

1955·21citations·D. Myers et al.·Nature

Nature

DOI: 10.1042/BJ0560185

Tricresyl phosphates and cholinesterase.

The metabolic mechanism of the flagellate is not consistent throughout its growth, with acetic acid being most active during the first 6 days and succinic acid being most active during the later stages.

1954·78citations·W. Aldridge·The Biochemical journal

The Biochemical journal

DOI: 10.1042/BJ0540583

Return of cholinesterase activity in the rat after inhibition by organophosphorus compounds. I. Diethyl p-nitro-phenyl phosphate (E 600, paraoxon).

Allylthiourea inhibition of nitrite formation in rats is due to chelation with copper, not competition with ammonia, supporting the theory that the enzyme involved in primary ammonia oxidation by Nitrosomonas is a copper enzyme.

1953·127citations·A. Davison·The Biochemical journal

The Biochemical journal

DOI: 10.1042/BJ0460451

Some properties of specific cholinesterase with particular reference to the mechanism of inhibition by diethyl p-nitrophenyl thiophosphate (E 605) and analogues.

Diethyl p-nitrophenyl thiophosphate (E 605) and analogues effectively inhibit cholinesterase, with their mode of action being primarily based on the kinetics of the inhibitor-enzyme system.

1950·421citations·W. Aldridge·The Biochemical journal

The Biochemical journal

Citations

DOI: 10.1016/j.ijheh.2024.114381

Biomonitoring of volatile organic compounds and organophosphorus flame retardands in commercial aircrews after "fume and smell events".

Aircrews' exposure to volatile organic compounds and organophosphorus compounds after "fume and smell events" is similar to that of the general population, with only elevated peak levels observed.

2024·0citations·T. Weiss et al.·International journal of hygiene and environmental health

International journal of hygiene and environmental health

DOI: 10.1590/S0004-282X1986000300003

Estudo das manifestações neurológicas em 93 doentes com intoxicação exógena por substancias químicas não medicamentosas

Herbicides and organophosphates show a clear preference for the central nervous system in cases of suspected exogenous intoxication, with carbamates and organochlorines showing similar tropism.

1986·2citations·Svetlana Agapejev et al.·Arquivos De Neuro-psiquiatria

Arquivos De Neuro-psiquiatria

DOI: 10.1016/0041-008X(86)90317-0

Lymphocyte and brain neurotoxic esterase: dose and time dependence of inhibition in the hen examined with three organophosphorus esters.

Assay of lymphocyte neurotoxic esterase can effectively monitor exposure to axonotoxic organophosphorus compounds within 24 hours of exposure.

1986·46citations·B. Schwab et al.·Toxicology and applied pharmacology

Toxicology and applied pharmacology

DOI: 10.1007/BF00286574

Phthalates and organophosphorus compounds as cholinesterase inhibitors in fractions of industrial hexane impurities

Phthalates and organophosphorus compounds are found in industrial hexane impurities, potentially playing a toxicological role in occupational neuropathies.

1985·2citations·J. Vicedo et al.·Archives of Toxicology

Archives of Toxicology

DOI: 10.2131/JTS.10.67

Studies on the delayed neurotoxicity of organophosphorus compounds--(III).

Repeated subcutaneous doses of TOCP cause delayed neurotoxicity in male S. D. rats, with ataxia occurring 50 days after injection and gradual recovery.

1981·11citations·H. Itoh et al.·The Journal of toxicological sciences

The Journal of toxicological sciences

DOI: 10.1136/oem.36.2.153

Effects of tricresylphosphate on esterase activity of rat serum and tissues.

Tricresylphosphate increases liver microsomal arylesterase and NADPH2-oxidase in male rats, but does not affect these enzymes in female rats.

1979·2citations·M. Manno et al.·British Journal of Industrial Medicine

British Journal of Industrial Medicine

DOI: 10.1016/0147-6513(79)90055-1

Measurement of neurotoxic esterase activity in various subcellular fractions of hen brain and sciatic nerve homogenates and the effect of diisopropyl fluorophosphate (DFP) administration.

Neurotoxic esterase activity is concentrated in microsomal fractions of brain and sciatic nerve, with inhibitory effects from diisopropyl fluorophosphate.

1979·3citations·E. Olajos et al.·Ecotoxicology and environmental safety

Ecotoxicology and environmental safety

DOI: 10.1016/S0147-6513(78)80011-6

Central and peripheral neurotoxic esterase activity and dose-response relationship in adult hens after acute and chronic oral administration of diisopropyl fluorophosphate.

Diisopropyl fluorophosphate (DFP) has a small inhibitory effect on brain neurotoxic esterase activities in adult hens, with quantitative differences between peripheral and central nervous system neurotoxic esterase content and activity.

1978·11citations·E. Olajos et al.·Ecotoxicology and environmental safety

Ecotoxicology and environmental safety