Nicotine demethylation in Nicotiana cell suspension cultures: N'-formylnornicotine is not involved.

doi:10.1016/J.PHYTOCHEM.2005.07.005

Paper

DOI: 10.1016/J.PHYTOCHEM.2005.07.005

Nicotine demethylation in Nicotiana cell suspension cultures: N'-formylnornicotine is not involved.

Published Oct 1, 2005 · T. A. Bartholomeusz, Ramneek K. Bhogal, R. Molinié

Phytochemistry

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Study Snapshot

N'-formylnornicotine is not an intermediate in nicotine demethylation, as it is derived from nornicotine and cotinine, not nicotine itself.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Evidence for the involvement of tetrahydrofolate in the demethylation of nicotine by Nicotiana plumbaginifolia cell-suspension cultures

Nicotiana plumbaginifolia cells can recycle nicotine's N-methyl group into primary metabolism, with 70-75% of metabolized label released as carbon dioxide.

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Synthesis of 15N‐labelled nornicotine and 15N‐labelled nicotine

This study demonstrates the first synthesis of 15N-labelled nicotine and nornicotine, with yields of 30% and 26%, respectively, from 3-bromopyridine.

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Chiral specificity of the degradation of nicotine by Nicotiana plumbaginifolia cell suspension cultures

Nicotiana plumbaginifolia cell suspension cultures rapidly degrade (R)-nicotine, but (S)-nicotine undergoes more rapid metabolism to unidentified products.

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Fast track to the trichome: induction of N-acyl nornicotines precedes nicotine induction in Nicotiana repanda

Nicotiana repanda plants produce N-acyl-nornicotines, which are more toxic to Manduca sexta herbivores, faster than nicotine, suggesting their importance in defense against herbivores.

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Citations

DOI: 10.3390/molecules27228105

Fractionation and Extraction Optimization of Potentially Valuable Compounds and Their Profiling in Six Varieties of Two Nicotiana Species

Tobacco plants can be a valuable source of valuable compounds with diverse applications beyond nicotine, with high variability in anatabine content and lower CGA and rutin content in the Burley variety compared to other varieties.

2022·5citations·Csaba Laszlo et al.·Molecules

Molecules

DOI: 10.1016/j.phytochem.2020.112424

Alkaloid chemophenetics and transcriptomics of the Nicotiana genus.

This study reveals that alkaloid accumulation in Nicotiana species is correlated with gene expression, providing insights for future scientific exploration of the genus.

2020·16citations·K. Kaminski et al.·Phytochemistry

Phytochemistry

DOI: 10.1080/15592324.2019.1710053

Development of a nornicotine-reduced flue-cured tobacco line via EMS mutagenesis of nicotine N-demethylase genes

Triple mutant nicotine N-demethylase genes can be used to develop new flue-cured tobacco varieties with lower levels of nornicotine and NNN, potentially benefiting smokers.

2020·1citation·Z. Song et al.·Plant Signaling & Behavior

Plant Signaling & Behavior

DOI: 10.1186/s12864-019-5446-2

Transcriptome analysis of genes and metabolic pathways associated with nicotine degradation in Aspergillus oryzae 112822

Nicotine tolerance and degradation in Aspergillus oryzae 112822 are regulated through complex networks involving detoxification, transport, and oxidative stress response, with increased energy investment driving detoxification.

2019·12citations·Chunjuan He et al.·BMC Genomics

BMC Genomics

DOI: 10.1039/C4GC01021C

A theoretical study of the nornicotine-catalyzed Mannich reaction in wet solvents and water

Nornicotine catalyzes the Mannich reaction in wet solvents and water, enabling a greener, faster C-C bond formation process.

2014·5citations·Sheng-Che Yang et al.·Green Chemistry

Green Chemistry