M. Fantin, C. Fischetti, C. Trapella
Oct 1, 2007
Citations
1
Influential Citations
21
Citations
Quality indicators
Journal
British Journal of Pharmacology
Abstract
Nocistatin (NST) is a neuropeptide generated from cleavage of the nociceptin/orphanin FQ (N/OFQ) precursor. Evidence has been presented that NST acts as a functional antagonist of N/OFQ, although NST receptor and transduction pathways have not yet been identified. We previously showed that N/OFQ inhibited [3H]5‐hydroxytryptamine ([3H]5‐HT) release from mouse cortical synaptosomes via activation of NOP receptors. We now investigate whether NST regulates [3H]5‐HT release in the same preparation.