Paper
Normal erythrocyte sedimentation rate with hyperfibrinogenemia in 6-sulfanilamidoindazole arthritis.
Published Mar 1, 1979 · M. Miller, C. Samuelson, J. Ward
The Journal of rheumatology
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Abstract
The erythrocyte sedimentation rate (ESR) is the most frequently employed laboratory indicator of inflammatory activity. The plasma fibrinogen concentration is usually increased in inflammatory disorders and is thought to contribute to the ESR elevation, 6-sulfanilamidoindazole induced arthritis in rats produces very high plasma fibrinogen concentrations and increased blood viscosity but no change in ESR.
In 6-sulfanilamidoindazole-induced arthritis in rats, high plasma fibrinogen concentrations and increased blood viscosity do not affect the erythrocyte sedimentation rate, suggesting that hyperfibrinogenemia may contribute to inflammation without affecting the ESR.
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