Low Nourishment of Vitamin C Induces Glutathione Depletion and Oxidative Stress in Healthy Young Adults.

doi:10.3746/pnf.2015.20.3.198

Paper

Low Nourishment of Vitamin C Induces Glutathione Depletion and Oxidative Stress in Healthy Young Adults.

Published Apr 13, 2015 · M. Waly, Z. Al-Attabi, N. Guizani

Preventive nutrition and food science

Q2 SJR score

10

Citations

0

Influential Citations

Full textSemantic Scholar

Abstract

The present study was conducted to assess the status of vitamin C among healthy young adults in relation to serum antioxidant parameters [glutathione (GSH), thiols, and total antioxidant capacity, (TAC)], and oxidative stress markers [malondialdehyde (MDA), and nitrites plus nitrates (NN)]. A prospective study included 200 young adults, and their dietary intake was assessed by using food diaries. Fasting plasma vitamin C, serum levels of GSH, thiols, TAC, MDA, and NN were measured using biochemical assays. It was observed that 38% of the enrolled subjects, n=76, had an adequate dietary intake of vitamin C (ADI group). Meanwhile, 62%, n=124, had a low dietary intake of vitamin C (LDI group) as compared to the recommended dietary allowances. The fasting plasma level of vitamin C was significantly higher in the ADI group as compared to the LDI group. Oxidative stress in the sera of the LDI group was evidenced by depletion of GSH, low thiols levels, impairment of TAC, an elevation of MDA, and increased NN. In the ADI group, positive correlations were found between plasma vitamin C and serum antioxidant parameters (GSH, thiols, and TAC). Meanwhile, the plasma vitamin C was negatively correlated with serum MDA and NN levels. This study reveals a significant increase of oxidative stress status and reduced antioxidant capacity in sera from healthy young adults with low intake of the dietary antioxidant, vitamin C.

Observational Study

Study Snapshot

Low vitamin C intake in healthy young adults leads to increased oxidative stress and reduced antioxidant capacity, affecting their overall health.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

Low Nourishment of Vitamin C Induces Glutathione Depletion and Oxidative Stress in Healthy Young Adults.

Sign up to use Study Snapshot

References

State of art and science advances on nutrition and nutrigenetics in nutrition-related non-communicable diseases in Middle East

Nutrition and nutrigenetics can play a crucial role in preventing and treating nutrition-related non-communicable diseases in the Middle East, with advances in technology and research advancing our understanding of food-gene interactions.

Métodos antropométricos utilizados na avaliação da retenção do peso no período pós-parto: uma revisão sistemática

There is a lack of well-defined information on anthropometric measurements of women after delivery, indicating the need for national proposals consistent with our population's reality.

Biochemical changes of oxidative stress in premature ovarian insufficiency induced by tripterygium glycosides.

Oxidative stress is involved in premature ovarian insufficiency induced by tripterygium glycosides, potentially contributing to its pathogenesis.

β-Sitosterol Protects against Carbon Tetrachloride Hepatotoxicity but not Gentamicin Nephrotoxicity in Rats via the Induction of Mitochondrial Glutathione Redox Cycling

-sitosterol protects against carbon tetrachloride-induced hepatotoxicity in rats by enhancing mitochondrial glutathione redox cycling, but not gentamicin nephrotoxicity, likely due to low bioavailability in kidneys.

The effect of weight reduction on antioxidant enzymes and their association with dietary intake of vitamins A, C and E.

Weight reduction of 10% can significantly increase antioxidant enzymes, particularly glutathione reductase and catalase, in obese women, but a balanced nutrient intake is crucial for optimal health.

Citations

Innovative Treatments to Counteract Endothelial Dysfunction in Chronic Kidney Disease Patients

Innovative non-pharmacological treatments, such as extra virgin olive oil, a plant-dominant, low-protein diet, and adaptive physical activity, can effectively counteract endothelial dysfunction in chronic kidney disease patients.

Redox Regulation in Age-Related Cataracts: Roles for Glutathione, Vitamin C, and the NRF2 Signaling Pathway

Proper redox regulation, involving glutathione, vitamin C, and the NRF2 signaling pathway, is crucial for maintaining lens clarity and preventing age-related cataracts.

Enhancing Supplemental Effects of Acute Natural Antioxidant Derived from Yeast Fermentation and Vitamin C on Sports Performance in Triathlon Athletes: A Randomized, Double-Blinded, Placebo-Controlled, Crossover Trial

Combined vitamin C and glutathione supplementation improves metabolic function, skeletal oxygenation, cardiac function, and antioxidant function during prolonged submaximal exercise in middle-aged triathletes.

An update of the effects of vitamins D and C in critical illness

Vitamin D and C supplementation in critically ill patients is cost-effective and safe, with optimal dosages varying based on the patient's condition.

The Protective Effect of Ascorbic Acid and Curcumin on the Chronic Toxicity of Meloxicam on the Testis of Adult Albino Rats

Curcumin and ascorbic acid both have a strong protective effect against meloxicam-induced testicular harm in adult albino rats at biochemical, histopathological, and ultrastructural levels.