Paper
Novel 6-[(hetero)arylamino]thieno[3,2-b]pyridines: synthesis and antitumoral activities.
Published Dec 1, 2010 · M. Queiroz, R. Calhelha, L. Vale-Silva
European journal of medicinal chemistry
Q2 SJR score
25
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0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Study Snapshot
Novel 6-[(hetero)arylamino]thieno[3,2-b]pyridines show promising antitumoral activity against breast, melanoma, and non-small cell lung cancer cell lines.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Synthesis of new thieno[3,2-b]pyridine derivatives by palladium-catalyzed couplings and intramolecular cyclizations
Palladium-catalyzed couplings and intramolecular cyclizations enable the synthesis of new thieno[3,2-b]pyridine derivatives, including di(hetero)arylamines and tetracyclic compounds.
2010·19citations·R. Calhelha et al.·Tetrahedron Letters
Tetrahedron Letters
Reactivity of several deactivated 3-aminobenzo[b]thiophenes in the Buchwald–Hartwig C–N coupling. Scope and limitations
Deactivated 3-aminobenzo[b]thiophenes can successfully perform C-N coupling with bromobenzenes and bromobiphenyls, potentially yielding biologically interesting tetracyclic compounds.
2007·19citations·M. Queiroz et al.·Tetrahedron
Tetrahedron
Synthesis and antioxidant activity evaluation of new 7-aryl or 7-heteroarylamino-2,3-dimethylbenzo[b]thiophenes obtained by Buchwald-Hartwig C-N cross-coupling.
New 7-aryl or 7-heteroarylamino-2,3-dimethylbenzo[b]thiophenes show promising antioxidant properties, with structure-activity relationships based on substituents and ring positions.
2007·36citations·M. Queiroz et al.·Bioorganic & medicinal chemistry
Bioorganic & medicinal chemistry
Inhibition of Src kinase activity by 7-[(2,4-dichloro-5-methoxyphenyl)amino]-2-heteroaryl-thieno[3,2-b]pyridine-6-carbonitriles.
The compounds with 3,5-furan or 2,5-pyridine at C-2 show the best activity as inhibitors of Src kinase activity in enzyme and cell assays.
2005·18citations·D. Boschelli et al.·Bioorganic & medicinal chemistry letters
Bioorganic & medicinal chemistry letters
Synthesis and Src kinase inhibitory activity of 2-phenyl- and 2-thienyl-7-phenylaminothieno[3,2-b]pyridine-6-carbonitriles.
Two-phenyl-7-phenylaminothieno[3,2-b]pyridine-6-carbonitriles show inhibitory activity against Src kinase, with some derivatives showing comparable activity to SKI-606, a related 3-quinolinecarbonitrile in clinical trials.
2005·36citations·D. Boschelli et al.·Journal of medicinal chemistry
Journal of medicinal chemistry
Citations
-Proline catalyzed synthesis of biologically promising heterocycles under sustainable conditions
L-proline catalyzed organic reactions enable the sustainable synthesis of biologically promising heterocycles under environmentally benign conditions, offering valuable tools for bio-active compound manufacturing.
2024·1citation·Rajiv Karmakar et al.·Tetrahedron Chem
Tetrahedron Chem
Magnetoliposomes Containing Multicore Nanoparticles and a New Antitumor Thienopyridine Compound with Potential Application in Chemo/Thermotherapy
Magnetoliposomes containing multicore nanoparticles and a new antitumor thienopyridine compound show potential for combined cancer therapy, offering potential for combined magnetic hyperthermia and chemotherapy.
2022·9citations·Fábio A. C. Lopes et al.·Biomedicines
Biomedicines
Development of Thermo- and pH-Sensitive Liposomal Magnetic Carriers for New Potential Antitumor Thienopyridine Derivatives
Magnetic liposomes with thermo- and pH-sensitivity can effectively deliver new antitumor thienopyridine derivatives for dual cancer therapy.
2022·9citations·B. C. Ribeiro et al.·Materials
Materials
Magnetoliposomes Based on Magnetic/Plasmonic Nanoparticles Loaded with Tricyclic Lactones for Combined Cancer Therapy
Magnetoliposomes loaded with tricyclic lactones effectively inhibit tumor cell growth when irradiated with red light, making them suitable for combined cancer therapy.
2021·7citations·I. Rio et al.·Pharmaceutics
Pharmaceutics
Synthesis of Novel Methyl 7-[(Hetero)arylamino]thieno[2,3-b]pyrazine-6-carboxylates and Antitumor Activity Evaluation: Effects in Human Tumor Cells Growth, Cell Cycle Analysis, Apoptosis and Toxicity in Non-Tumor Cells
Novel methyl 7-[(hetero)arylamino]thieno[2,3-b]pyrazine-6-carboxylates show promising antitumoral activity against various human tumor cell lines without significant toxicity, suggesting a different mechanism of action.
2021·3citations·Juliana M. Rodrigues et al.·Molecules
Molecules
Application of PEG400 in the one-pot synthesis of 7-[4-alkyl- or (hetero)aryl-1H-1,2,3-triazol-1-yl]thieno[3,2-b]pyridines via SNAr and Cu(I)-Catalyzed Azide-Alkyne Cycloaddition and preliminary evaluation of their anti-tumour activity
PEG 400 enables the one-pot synthesis of novel anti-tumor compounds, with a 2-ethynylpyridine derivative showing promising anti-tumor activity.
2020·5citations·Juliana M. Rodrigues et al.·Tetrahedron Letters
Tetrahedron Letters
Novel dehydropeptide-based magnetogels containing manganese ferrite nanoparticles as antitumor drug nanocarriers.
Magnetogels containing manganese ferrite nanoparticles show potential as nanocarriers for antitumor drugs, with the RGD sequence magnetogel showing promise for thienopyridine delivery and three magnetogels suitable for curcumin delivery.
2019·13citations·S. R. Veloso et al.·Physical chemistry chemical physics : PCCP
Physical chemistry chemical physics : PCCP
Synthesis of novel 8-(het)aryl-6H-pyrano[4′,3′:4,5]thieno[3,2-b]pyridines by 6-endo-dig cyclization of Sonogashira products and halolactonizations with Cu salts/NXS. Preliminary antitumor evaluation
Novel 8-(het)aryl-6H-pyrano[4,3′:4,5]thieno[3,2-b]pyridines show promising antitumor activity, with a tricyclic lactone with a F atom in the meta position showing the most promising potential.
2019·10citations·Juliana M. Rodrigues et al.·Tetrahedron
Tetrahedron