L. VandeVrede, E. Tavassoli, Jia Luo
Jan 1, 2014
Citations
1
Influential Citations
16
Citations
Journal
British Journal of Pharmacology
Abstract
Chlormethiazole (CMZ), a clinical sedative/anxiolytic agent, did not reach clinical efficacy in stroke trials despite neuroprotection demonstrated in numerous animal models. Using CMZ as a lead compound, neuroprotective methiazole (MZ) analogues were developed, and neuroprotection and GABAA receptor dependence were studied.