H. Chun
2013
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Journal
Fine Chemical Intermediates
Abstract
4-Aminoacetophenone was synthesized from 4-hydroxyacetophenone and 2-bromo-2-methylpropanamide via Williamson etherification,Smiles rearrangement and hydrolysis reactions.Best result with 52.1% yield was obtained under conditions of reaction dissolvent of DMA,reaction temperature of 45℃~50℃ in rearrangement reaction,molar ratio of 4-hydroxyacetophenone to 2-bromo-2-methylpropanamide of 1 to 3.The structure of the title compound was confirmed by 1H NMR and IR.