M. Mouhtaram, L. Jung, J. Stambach
Feb 12, 1993
Citations
0
Influential Citations
10
Citations
Journal
Tetrahedron
Abstract
Abstract Addition of benzylamine or methylamine to 4-chloro-β-nitrostyrene 2 allowed the successful obtention of 1-phenylethylene-1,2-diamines 5,6. The intermediate nitrocompounds 3,4 were isolated and then reduced in acidic conditions. Selective ethylation of primary amine group to 11, 12 followed by cyclization with 1,2-dibromopropionitrile or ethyl 1,2-dibromopropionate led to substituted 6-phenylpiperazines 13–18. The stereoisomers were separated and unambiguously identified by a spectroscopic study.