New N-(phenoxydecyl)phthalimide derivatives displaying potent inhibition activity towards alpha-glucosidase.

doi:10.1016/j.bmc.2010.06.088

Paper

New N-(phenoxydecyl)phthalimide derivatives displaying potent inhibition activity towards alpha-glucosidase.

Published Aug 15, 2010 · R. Pascale, A. Carocci, Alessia Catalano

Bioorganic & medicinal chemistry

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46

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Abstract

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In Vitro Study

Study Snapshot

New N-(phenoxydecyl)phthalimide derivatives show potent alpha-glucosidase inhibition activity, with 10 carbon substrates being the most active, and electron-withdrawing substituents at the phenoxy group playing a critical role.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

New N-(phenoxydecyl)phthalimide derivatives displaying potent inhibition activity towards alpha-glucosidase.

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References

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Novel isoluminol probes, derived from peptides mimicking bacteriophage attachment proteins, may offer high sensitivity and shorter preparation and assay time in rapid bacterial assays compared to conventional methods.

Synthesis and Biological Characterisation of Novel N‐Alkyl‐Deoxynojirimycin α‐Glucosidase Inhibitors

The novel N-alkyl-deoxynojirimycin glucosidase inhibitor effectively inhibits glucosidase I and cellular ER glucosidases, offering potential therapeutic applications.

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This study presents a simple, efficient, and mild method for the synthesis of omega-aminoalkyl 2-deoxy- and 2,3-dideoxy-d-hexopyranosides using tri-O-acetyl-D-glucal and -D-galactal.

Inhibitory effect on α-glucosidase by Adhatoda vasica Nees.

The methanolic extract from Adhatoda vasica Nees leaves shows high sucrase inhibitory activity, suggesting potential as an antidiabetic agent and treatment for metabolic disorders.

Gypsophin: a novel alpha-glucosidase inhibitory cyclic peptide from the roots of Gypsophila oldhamiana.

Gypsophin, a novel alpha-glucosidase inhibitory cyclic peptide from Gypsophila oldhamiana roots, shows promising potential as a potential drug for diabetes treatment.

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