N-substituted benzamides inhibit NFκB activation and induce apoptosis by separate mechanisms

doi:10.1038/sj.bjc.6690796

Paper

N-substituted benzamides inhibit NFκB activation and induce apoptosis by separate mechanisms

Published Nov 1, 1999 · D. Liberg, B. Lazarevic, R. Pero

British Journal of Cancer

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11

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1

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Abstract

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In Vitro Study

Study Snapshot

N-substituted benzamides induce apoptosis and inhibit NFB activation, offering potential as radio- and chemo-sensitizers and anti-inflammatory compounds targeting NFB.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

N-substituted benzamides inhibit NFκB activation and induce apoptosis by separate mechanisms

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References

Citations

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N,N'-1,2-Phenylenebis(4-(chloromethyl)benzamide)

N,N'-1,2-Phenylenebis(4-(chloromethyl)benzamide) (3) was successfully synthesized in 61% yield by nucleophilic acyl substitution of 4-(chloromethyl)benzoyl chloride with 1,2-phenylenediamine under basic conditions.