Nucleotides. Part XXVII Bis[2-(p-nitrophenyl)ethyl] Phosphorochloridate, a New Versatile Phosphorylating Agent in Nucleotide Chemistry†

doi:10.1002/HLCA.19870700508

Paper

Nucleotides. Part XXVII Bis[2-(p-nitrophenyl)ethyl] Phosphorochloridate, a New Versatile Phosphorylating Agent in Nucleotide Chemistry†

Published Aug 12, 1987 · F. Himmelsbach, R. Charubala, W. Pfleiderer

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Abstract

A new, versatile phosphorylating agent, bis[2-(p-nitrophenyl)ethyl] phosphorochloridate (3), has been prepared and is used for 3′- and/or 5′-phosphorylations of nucleosides. The resulting bis[2-(p-nitrophenyl)ethyl] phosphotriesters are versatile synthons in oligonucleotide synthesis leading finally to 3′- and/or 5′-terminated monophosphates in excellent yields.

Study Snapshot

Bis[2-(p-nitrophenyl)ethyl] phosphorochloridate (3) is a versatile phosphorylating agent for nucleoside synthesis, resulting in versatile synthons for oligonucleotide synthesis in excellent yields.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Nucleotides. Part XXVII Bis[2-(p-nitrophenyl)ethyl] Phosphorochloridate, a New Versatile Phosphorylating Agent in Nucleotide Chemistry†

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References

Citations

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