Paper
Observations on the action of hexamethonium bromide in tourniquet shock in rats.
Published Sep 1, 1955 ยท W. Spoerel
Canadian journal of biochemistry and physiology
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Abstract
Rats subjected to tourniquet shock were treated with hexamethonium bromide (C6), a ganglionic blocking agent. The effect of this agent on survival, blood pressure, fluid loss, and hemoconcentration was studied. Hemoglobin as determined by the cyanhemoglobin method was used as an indicator of hemoconcentration. The fluid loss into the injured hindlegs was measured by the estimation of the fluid content of muscle tissue. The survival rate was significantly improved by administration of C6 at the time the tourniquets were released. Treatment with C6 two and four hours after tourniquet release provided little or no protection. No difference in fluid loss could be detected between treated and untreated rats, but the hemoconcentration was less in treated animals and followed a different pattern. Treated rats showed no blood pressure response to the release of the tourniquets. The protection provided by C6 is thought to be due mainly to its effect on the general circulation.
Non-RCT
Animal StudyHexamethonium bromide significantly improves survival rate in rats subjected to tourniquet shock when administered at the time of tourniquet release, with no significant difference in fluid loss or hemoconcentration.
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