W. Pan, D. Dong, Kewei Wang
May 16, 2007
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0
Influential Citations
68
Citations
Journal
Organic letters
Abstract
A facile and efficient one-pot synthesis of highly substituted pyridin-2(1H)-ones is developed via the Vilsmeier-Haack reaction of readily available 1-acetyl,1-carbamoyl cyclopropanes, and a mechanism involving sequential ring-opening, haloformylation, and intramolecular nucleophilic cyclization reactions is proposed.